Enterohaemorrhagic Escherichia coli (EHEC) binds to host tissue and intimately attaches to
intestinal cells using a dedicated type III secretion system (T3SS). This complex multi-protein …

Shiga toxin-producing Escherichia coli (STEC) is a global foodborne bacterial pathogen that
is often accountable for colon disorder or distress. STEC commonly induces severe diarrhea …

A class of anti-virulence compounds, the salicylidene acylhydrazides, has been widely
reported to block the function of the type three secretion system of several Gram-negative …

The ability of any organism to sense and respond to challenges presented in the
environment is critically important for promoting or restricting colonization of specific sites …

The NFκB transcription factor is a key component of immune and inflammatory signaling as
its activation induces the expression of antimicrobial reagents, chemokines, cytokines, and …

The human pathogen enterohemorrhagic Escherichia coli (EHEC) O157: H7 has two
histidine sensor kinases, QseC and QseE, which respond to the mammalian adrenergic …

Hfq is a conserved RNA‐binding protein that regulates diverse cellular processes through
post‐transcriptional control of gene expression, often by functioning as a chaperone for …

Type III secretion (T3S) systems enable the injection of bacterial proteins through membrane
barriers into host cells, either from outside the host cell or from within a vacuole. This system …

Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of zoonotic diarrhoeal
pathogens of worldwide importance. Cattle are a key reservoir; however the molecular …

Colonization of the intestinal epithelium by enterohaemorrhagic Escherichia coli (EHEC) is
characterized by an attaching and effacing (A/E) histopathology. The locus of enterocyte …