Abstract Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is one of the most important proliferative signaling pathways with critical …

In cancerous cells, significant changes occur in the activity of signaling pathways affecting a
wide range of cellular activities ranging from growth and proliferation to apoptosis …

Simple Summary Healthy diet and physical activity are able to induce beneficial molecular
modifications that have been associated with a lower risk of breast cancer (BC) incidence …

Breast cancer remains the most common malignancy in women worldwide. Circular RNAs
(circRNAs) are a newly validated type of endogenous non-coding RNAs and accumulating …

The high incidence of breast cancer is the greastest threat to women'health all over the
world. Among them, HER-2 positive breast cancer has the characteristics of high …

The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal
herbs. Quercetin has been a focal point in recent years due to its versatile health‐promoting …

Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate
due to its infiltrative growth, treatment resistance, intra-and intertumoral genetic …

Simultaneous detection of the concentration variations of microRNA-221 (miRNA-221) and
PTEN mRNA molecules in the PI3K/AKT signaling pathway is of significance to elucidate …

Simple Summary Tumor cell invasiveness and metastasis are key processes in cancer
progression and are composed of many steps. All of them are regulated by multiple …

In order to obtain new anti-hepatoma drugs with low toxicity, some 1, 4, 5, 6, 7, 8-
hexahydropyrido [4, 3-d] pyrimidines (PPMs, 4a-t) were synthesized in this study. Many of …