Mitochondria sense changes resulting from the ischemia and subsequent reperfusion of an
organ and mitochondrial reactive oxygen species (ROS) production initiates a series of …

Highlights•Static cold storage is a key bottleneck for all regenerative medicine
therapies.•Machine perfusion is an important emerging organ preservation …

Preservation of human organs at subzero temperatures has been an elusive goal for
decades. The major complication hindering successful subzero preservation is the formation …

This study was motivated by the increasing interest in finding ways to preserve organs in a
supercooled state for transplantation. Previous research with small volumes suggests that …

In recent years there have been several advancements in organ preservation that have yet
to see widespread clinical translation. While static cold storage (SCS) at 2° C–4° C …

The disparity between the number of available donor livers and patients awaiting a liver
transplant has led transplant centers to accept suboptimal livers. There has been no …

We present herein an experimental study on the ice-nucleation kinetics of two recently
introduced aqueous supercooling modalities—oil-sealed isobaric supercooling and …

The liver viability monitoring during its procurement is critical to guarantee the safe liver
transportation. Traditionally, the viability is assessed by taking invasive biopsy on the liver …

Supercooled preservation (SCP) is a technology that involves cooling a substance below its
freezing point without initiating ice crystal formation. It is a promising alternative to prolong …

This chapter covers the key physical, biological and practical challenges encountered when
developing cryopreservation protocols for larger biological structures and examines areas …