Background Neutrophil-to-lymphocyte ratio (NLR) has been used to predict the prognosis of
patients with sepsis with inconsistent results. This meta-analysis aimed to clarify the …

Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Delphi is a scientific method to organize and structure an expert discussion aiming to
generate insights on controversial topics with limited information. The technique has seen a …

Purpose Severe community-acquired pneumonia (CAP) requiring intensive care unit
admission is associated with significant acute and long-term morbidity and mortality. We …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

The “sepsis bundle” has been central to the implementation of the Surviving Sepsis
Campaign (SSC) from the first publication of its evidence-based guidelines in 2004 through …

Background Septic shock is characterized by dysregulation of the host response to infection,
with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with …