Network propagation: a universal amplifier of genetic associations
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
Incorporating machine learning into established bioinformatics frameworks
N Auslander, AB Gussow, EV Koonin - International journal of molecular …, 2021 - mdpi.com
The exponential growth of biomedical data in recent years has urged the application of
numerous machine learning techniques to address emerging problems in biology and …
numerous machine learning techniques to address emerging problems in biology and …
Discovering symptom patterns of COVID-19 patients using association rule mining
Background The COVID-19 pandemic is a significant public health crisis that is hitting hard
on people's health, well-being, and freedom of movement, and affecting the global economy …
on people's health, well-being, and freedom of movement, and affecting the global economy …
The genetics and pathogenesis of CAKUT
CM Kolvenbach, S Shril, F Hildebrandt - Nature Reviews Nephrology, 2023 - nature.com
Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …
malformations that arise from defective kidney or urinary tract development and frequently …
Drug target prediction and repositioning using an integrated network-based approach
D Emig, A Ivliev, O Pustovalova, L Lancashire… - PloS one, 2013 - journals.plos.org
The discovery of novel drug targets is a significant challenge in drug development. Although
the human genome comprises approximately 30,000 genes, proteins encoded by fewer than …
the human genome comprises approximately 30,000 genes, proteins encoded by fewer than …
Recent advances in network-based methods for disease gene prediction
Disease–gene association through genome-wide association study (GWAS) is an arduous
task for researchers. Investigating single nucleotide polymorphisms that correlate with …
task for researchers. Investigating single nucleotide polymorphisms that correlate with …
Integrating gene expression and protein-protein interaction network to prioritize cancer-associated genes
Background To understand the roles they play in complex diseases, genes need to be
investigated in the networks they are involved in. Integration of gene expression and …
investigated in the networks they are involved in. Integration of gene expression and …
Computational approaches for the identification of cancer genes and pathways
CM Dimitrakopoulos… - … Reviews: Systems Biology …, 2017 - Wiley Online Library
High‐throughput DNA sequencing techniques enable large‐scale measurement of somatic
mutations in tumors. Cancer genomics research aims at identifying all cancer‐related genes …
mutations in tumors. Cancer genomics research aims at identifying all cancer‐related genes …
TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery
Prioritising candidate genes for further experimental characterisation is a non-trivial
challenge in drug discovery and biomedical research in general. An integrated approach …
challenge in drug discovery and biomedical research in general. An integrated approach …
THBS2 is a potential prognostic biomarker in colorectal cancer
X Wang, L Zhang, H Li, WJ Sun, H Zhang, M Lai - Scientific reports, 2016 - nature.com
Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic
at an early stage is a useful way that decrease and avoid mortality. Although remarkable …
at an early stage is a useful way that decrease and avoid mortality. Although remarkable …