Network propagation: a universal amplifier of genetic associations

L Cowen, T Ideker, BJ Raphael, R Sharan - Nature Reviews Genetics, 2017 - nature.com
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …

Incorporating machine learning into established bioinformatics frameworks

N Auslander, AB Gussow, EV Koonin - International journal of molecular …, 2021 - mdpi.com
The exponential growth of biomedical data in recent years has urged the application of
numerous machine learning techniques to address emerging problems in biology and …

Discovering symptom patterns of COVID-19 patients using association rule mining

M Tandan, Y Acharya, S Pokharel… - Computers in biology and …, 2021 - Elsevier
Background The COVID-19 pandemic is a significant public health crisis that is hitting hard
on people's health, well-being, and freedom of movement, and affecting the global economy …

The genetics and pathogenesis of CAKUT

CM Kolvenbach, S Shril, F Hildebrandt - Nature Reviews Nephrology, 2023 - nature.com
Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …

Drug target prediction and repositioning using an integrated network-based approach

D Emig, A Ivliev, O Pustovalova, L Lancashire… - PloS one, 2013 - journals.plos.org
The discovery of novel drug targets is a significant challenge in drug development. Although
the human genome comprises approximately 30,000 genes, proteins encoded by fewer than …

Recent advances in network-based methods for disease gene prediction

SK Ata, M Wu, Y Fang, L Ou-Yang… - Briefings in …, 2021 - academic.oup.com
Disease–gene association through genome-wide association study (GWAS) is an arduous
task for researchers. Investigating single nucleotide polymorphisms that correlate with …

Integrating gene expression and protein-protein interaction network to prioritize cancer-associated genes

C Wu, J Zhu, X Zhang - BMC bioinformatics, 2012 - Springer
Background To understand the roles they play in complex diseases, genes need to be
investigated in the networks they are involved in. Integration of gene expression and …

Computational approaches for the identification of cancer genes and pathways

CM Dimitrakopoulos… - … Reviews: Systems Biology …, 2017 - Wiley Online Library
High‐throughput DNA sequencing techniques enable large‐scale measurement of somatic
mutations in tumors. Cancer genomics research aims at identifying all cancer‐related genes …

TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery

YA Chen, LP Tripathi, K Mizuguchi - PloS one, 2011 - journals.plos.org
Prioritising candidate genes for further experimental characterisation is a non-trivial
challenge in drug discovery and biomedical research in general. An integrated approach …

THBS2 is a potential prognostic biomarker in colorectal cancer

X Wang, L Zhang, H Li, WJ Sun, H Zhang, M Lai - Scientific reports, 2016 - nature.com
Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic
at an early stage is a useful way that decrease and avoid mortality. Although remarkable …