Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Abstract The cytokine interleukin-17 (IL-17) has received considerable attention since the
discovery of a distinct CD4+ T helper (TH) cell subset that produces it, known as the TH17 …

Summary Interleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune
system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it …

For all microorganisms, acquisition of metal ions is essential for survival in the environment
or in their infected host. Metal ions are required in many biological processes as …

Lung epithelial cells are increasingly recognized to be active effectors of microbial defense,
contributing to both innate and adaptive immune function in the lower respiratory tract. As …

Both, mammalian cells and microbes have an essential need for iron, which is required for
many metabolic processes and for microbial pathogenicity. In addition, cross-regulatory …

The siderophore aerobactin is the dominant siderophore produced by hypervirulent
Klebsiella pneumoniae (hvKP) and was previously shown to be a major virulence factor in …

Systematic characterization of cancer genomes has revealed a staggering number of
diverse aberrations that differ among individuals, such that the functional importance and …