Recent advances in the area of bacterial DNA damage responses are reviewed here. The
SOS pathway is still the major paradigm of bacterial DNA damage response, and recent …

Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic
and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms …

To construct a superior microbial cell factory for chemical synthesis, a major challenge is to
fully exploit cellular potential by identifying and engineering beneficial gene targets in …

Staphylococcus aureus is a common cause of both superficial and invasive infections of
humans and animals. Despite a potent host response and apparently appropriate antibiotic …

Adaptive response is a phenomenon in which cells which were pre-exposed to extremely
low and non-toxic doses of a genotoxic agent became resistant to the damage induced by …

微生物细胞在自然环境或工业应用中经常受到酸胁迫, 严重制约细胞生长性能和产物合成效率.
为了在各种酸性环境中生存, 耐酸细菌发展出多种保护机制来维持细胞内pH 稳态 …

Alkylating agents, which are widespread in the environment, also occur endogenously as
primary and secondary metabolites. Such compounds have intrinsically extremely cytotoxic …

This study assessed the clonal diversity, the resistance profile and the virulence potential of
Escherichia coli strains isolated from diabetic foot infection (DFI) and diabetic foot …

Alkylating agents are widespread in the environment and also occur endogenously. They
can be cytotoxic or mutagenic to the cells introducing alkylated bases to DNA or RNA. All …

The EcoCyc database is an online scientific database which provides an integrated view of
the metabolic and regulatory network of the bacterium Escherichia coli K-12 and facilitates …