The “silent” global burden of congenital cytomegalovirus

S Manicklal, VC Emery, T Lazzarotto… - Clinical microbiology …, 2013 - Am Soc Microbiol
Human cytomegalovirus (CMV) is a leading cause of congenital infections worldwide. In the
developed world, following the virtual elimination of circulating rubella, it is the commonest …

Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant

MG Revello, G Gerna - Clinical microbiology reviews, 2002 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection and
mental retardation. HCMV infection, while causing asymptomatic infections in most …

Congenital viral infection: traversing the uterine-placental interface

L Pereira - Annual review of virology, 2018 - annualreviews.org
Why certain viruses cross the physical barrier of the human placenta but others do not is
incompletely understood. Over the past 20 years, we have gained deeper knowledge of …

Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention

MCJ Cheeran, JR Lokensgard… - Clinical microbiology …, 2009 - Am Soc Microbiol
Congenital cytomegalovirus (CMV) infection is the leading infectious cause of mental
retardation and hearing loss in the developed world. In recent years, there has been an …

Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2

T Compton, EA Kurt-Jones, KW Boehme… - Journal of …, 2003 - Am Soc Microbiol
Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes
significant morbidity and mortality in immuncompromised people. An understanding of how …

The human cytomegalovirus

S Landolfo, M Gariglio, G Gribaudo, D Lembo - Pharmacology & …, 2003 - Elsevier
Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause
of birth defects, as well as an important pathogen for immunocompromised individuals. The …

Latency and reactivation of human cytomegalovirus

J Sinclair, P Sissons - Journal of General Virology, 2006 - microbiologyresearch.org
Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal
human host, maintained at least in part by its carriage in the absence of detectable infectious …

Human cytomegalovirus latency: approaching the Gordian knot

F Goodrum - Annual review of virology, 2016 - annualreviews.org
Herpesviruses have evolved exquisite virus-host interactions that co-opt or evade a number
of host pathways to enable the viruses to persist. Persistence of human cytomegalovirus …

Human cytomegalovirus latency and reactivation in allogeneic hematopoietic stem cell transplant recipients

L Stern, B Withers, S Avdic, D Gottlieb… - Frontiers in …, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) reactivation is a major infectious cause of morbidity and
mortality after allogeneic hematopoietic stem cell transplantation (HSCT). HCMV is a …

Molecular determinants and the regulation of human cytomegalovirus latency and reactivation

D Collins-McMillen, J Buehler, M Peppenelli… - Viruses, 2018 - mdpi.com
Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …