BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Highlights•Recurrent connectivity is anatomically and functionally prevalent in fly memory
circuits.•Sustained reverberant activity is necessary for memory consolidation.•Feedforward …

Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

Due to advances in automated image acquisition and analysis, whole-brain connectomes
with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated …

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …

Associating stimuli with positive or negative reinforcement is essential for survival, but a
complete wiring diagram of a higher-order circuit supporting associative memory has not …

Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …

Associating multiple sensory cues with objects and experience is a fundamental brain
process that improves object recognition and memory performance. However, neural …

Learned and adaptive behaviors rely on neural circuits that flexibly couple the same sensory
input to alternative output pathways. Here, we show that the Drosophila mushroom body …

The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …