Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …

Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

Phosphatidic acid (PA) is an essential phospholipid involved in membrane biosynthesis and
signal transduction in all eukaryotes. This review focuses on its role as lipid second …

Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

Lipid second messengers have essential roles in cellular function and contribute to the
molecular mechanisms that underlie inflammation, malignant transformation, invasiveness …

Accurate simulation of complex lipid bilayers has long been a goal in condensed phase
molecular dynamics (MD). Structure and function of membrane-bound proteins are highly …

Lipids function not only as the major structural components of cell membranes, but also as
molecular messengers that transduce signals to trigger downstream signaling events in the …

Glycerophospholipids are the most abundant membrane lipid constituents in most
eukaryotic cells. As a consequence, phospholipid class and acyl chain homeostasis are …

Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …