[HTML][HTML] Adenovirus core proteins: structure and function

S Kulanayake, SK Tikoo - Viruses, 2021 - mdpi.com
Adenoviruses have served as a model for investigating viral-cell interactions and
discovering different cellular processes, such as RNA splicing and DNA replication. In …

[HTML][HTML] Components of adenovirus genome packaging

YS Ahi, SK Mittal - Frontiers in microbiology, 2016 - frontiersin.org
Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes.
Genome packaging in AdV is thought to be similar to that seen in dsDNA containing …

[HTML][HTML] AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes

W Su, LW Seymour, R Cawood - Scientific Reports, 2023 - nature.com
Efficient manufacture of recombinant adeno-associated virus (rAAV) vectors for gene
therapy remains challenging. Packaging cell lines containing stable integration of the AAV …

[HTML][HTML] Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly …

GN Condezo, C San Martín - PLoS pathogens, 2017 - journals.plos.org
Adenovirus (AdV) morphogenesis is a complex process, many aspects of which remain
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …

[HTML][HTML] Use of an Integrated Approach Involving AlphaFold Predictions for the Evolutionary Taxonomy of Duplodnaviria Viruses

P Evseev, D Gutnik, M Shneider, K Miroshnikov - Biomolecules, 2023 - mdpi.com
The evaluation of the evolutionary relationships is exceptionally important for the taxonomy
of viruses, which is a rapidly expanding area of research. The classification of viral groups …

[HTML][HTML] Seeing and touching adenovirus: Complementary approaches for understanding assembly and disassembly of a complex virion

PJ de Pablo, C San Martín - Current opinion in virology, 2022 - Elsevier
Highlights•Cryo-EM has solved the structure of various adenovirus capsids, but not of the
core.•AFM probes biomechanics and induces/monitors disassembly of individual …

Formation of adenovirus DNA replication compartments and viral DNA accumulation sites by host chromatin regulatory proteins including NPM1

MJ Genoveso, M Hisaoka, T Komatsu… - The FEBS …, 2020 - Wiley Online Library
The adenovirus (Ad) genome is believed to be packaged into the virion by forming a
chromatin‐like structure. The replicated viral genome is likely to be condensed through …

[HTML][HTML] Functional characterization of a DNA-dependent AAA ATPase in a F-cluster mycobacteriophage

R Das, U Bajpai - Virus Research, 2023 - Elsevier
Mycobacteriophages are viruses of Mycobacterium spp. with promising diagnostic and
therapeutic potential. Phage genome exploration and characterization of their proteomes …

A novel role for the adenovirus L4 region 22K and 33K proteins in adeno-associated virus production

A Adsero, B Chestnut, S Shahnejat-Bushehri… - Human Gene …, 2024 - liebertpub.com
Despite decades of research in adeno-associated virus (AAV) and the role of adenovirus in
production, the interplay of AAV and adenovirus is not fully understood. Specific regions of …

[HTML][HTML] Adenoviral E4 34K protein interacts with virus packaging components and may serve as the putative portal

YS Ahi, AO Hassan, SV Vemula, K Li, W Jiang… - Scientific reports, 2017 - nature.com
Studies on dsDNA bacteriophages have revealed that a DNA packaging complex
assembles at a special vertex called the 'portal vertex'and consists of a portal, a DNA …