[HTML][HTML] Adenovirus core proteins: structure and function
S Kulanayake, SK Tikoo - Viruses, 2021 - mdpi.com
Adenoviruses have served as a model for investigating viral-cell interactions and
discovering different cellular processes, such as RNA splicing and DNA replication. In …
discovering different cellular processes, such as RNA splicing and DNA replication. In …
[HTML][HTML] Components of adenovirus genome packaging
Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes.
Genome packaging in AdV is thought to be similar to that seen in dsDNA containing …
Genome packaging in AdV is thought to be similar to that seen in dsDNA containing …
[HTML][HTML] AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes
W Su, LW Seymour, R Cawood - Scientific Reports, 2023 - nature.com
Efficient manufacture of recombinant adeno-associated virus (rAAV) vectors for gene
therapy remains challenging. Packaging cell lines containing stable integration of the AAV …
therapy remains challenging. Packaging cell lines containing stable integration of the AAV …
[HTML][HTML] Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly …
GN Condezo, C San Martín - PLoS pathogens, 2017 - journals.plos.org
Adenovirus (AdV) morphogenesis is a complex process, many aspects of which remain
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …
[HTML][HTML] Use of an Integrated Approach Involving AlphaFold Predictions for the Evolutionary Taxonomy of Duplodnaviria Viruses
P Evseev, D Gutnik, M Shneider, K Miroshnikov - Biomolecules, 2023 - mdpi.com
The evaluation of the evolutionary relationships is exceptionally important for the taxonomy
of viruses, which is a rapidly expanding area of research. The classification of viral groups …
of viruses, which is a rapidly expanding area of research. The classification of viral groups …
[HTML][HTML] Seeing and touching adenovirus: Complementary approaches for understanding assembly and disassembly of a complex virion
PJ de Pablo, C San Martín - Current opinion in virology, 2022 - Elsevier
Highlights•Cryo-EM has solved the structure of various adenovirus capsids, but not of the
core.•AFM probes biomechanics and induces/monitors disassembly of individual …
core.•AFM probes biomechanics and induces/monitors disassembly of individual …
Formation of adenovirus DNA replication compartments and viral DNA accumulation sites by host chromatin regulatory proteins including NPM1
The adenovirus (Ad) genome is believed to be packaged into the virion by forming a
chromatin‐like structure. The replicated viral genome is likely to be condensed through …
chromatin‐like structure. The replicated viral genome is likely to be condensed through …
[HTML][HTML] Functional characterization of a DNA-dependent AAA ATPase in a F-cluster mycobacteriophage
Mycobacteriophages are viruses of Mycobacterium spp. with promising diagnostic and
therapeutic potential. Phage genome exploration and characterization of their proteomes …
therapeutic potential. Phage genome exploration and characterization of their proteomes …
A novel role for the adenovirus L4 region 22K and 33K proteins in adeno-associated virus production
A Adsero, B Chestnut, S Shahnejat-Bushehri… - Human Gene …, 2024 - liebertpub.com
Despite decades of research in adeno-associated virus (AAV) and the role of adenovirus in
production, the interplay of AAV and adenovirus is not fully understood. Specific regions of …
production, the interplay of AAV and adenovirus is not fully understood. Specific regions of …
[HTML][HTML] Adenoviral E4 34K protein interacts with virus packaging components and may serve as the putative portal
Studies on dsDNA bacteriophages have revealed that a DNA packaging complex
assembles at a special vertex called the 'portal vertex'and consists of a portal, a DNA …
assembles at a special vertex called the 'portal vertex'and consists of a portal, a DNA …