As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …

Attention-deficit hyperactivity disorder (ADHD) is a common childhood-onset psychiatric
disorder characterized by inattention, impulsivity and hyperactivity. ADHD exhibits …

Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX).
The mGluR Theory of FX predicts that pathological synaptic changes arise from the …

CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules
with a meticulously described dual role in cell adhesion and β-catenin signaling. During …

The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the
brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a …

Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease
characterized by fibrofatty replacement of the right and left ventricle, often causing …

Purpose Genomic sequencing has become an increasingly powerful and relevant tool to be
leveraged for the discovery of genetic aberrations underlying rare, Mendelian conditions …

The neocortex is an exquisitely organized structure achieved through complex cellular
processes from the generation of neural cells to their integration into cortical circuits after …