Small molecule inhibitors targeting biosynthesis of ceramide, the central hub of the sphingolipid network

J Skácel, BS Slusher, T Tsukamoto - Journal of medicinal …, 2021 - ACS Publications
Ceramides are composed of a sphingosine and a single fatty acid connected by an amide
linkage. As one of the major classes of biologically active lipids, ceramides and their …

[HTML][HTML] Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence

WS Chew, F Torta, S Ji, H Choi, H Begum, X Sim… - JCI insight, 2019 - ncbi.nlm.nih.gov
BACKGROUND Sphingolipids (SPs) are ubiquitous, structurally diverse molecules that
include ceramides, sphingomyelins (SMs), and sphingosines. They are involved in various …

Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment

XY Chua, YL Chai, WS Chew, JR Chong… - Alzheimer's Research & …, 2020 - Springer
Background There has been ongoing research impetus to uncover novel blood-based
diagnostic and prognostic biomarkers for Alzheimer's disease (AD), vascular dementia …

A Sphingolipidomic Profiling Approach for Comparing X-ray-Exposed and Unexposed HepG2 Cells

M Moggio, B Faramarzi, M Portaccio, L Manti… - International Journal of …, 2023 - mdpi.com
An analytical method based on tandem mass spectrometry-shotgun is presently proposed to
obtain sphingolipidomic profiles useful for the characterization of lipid extract from X-ray …

Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

Q Chen, W Wang, MF Xia, Y Lu, H Bian, C Yu… - Journal of Translational …, 2021 - Springer
Abstract Background Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to
sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and …

Targeted lipidomics reveals associations between serum sphingolipids and insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp

J Ye, X Ye, W Jiang, C Lu, X Geng, C Zhao… - Diabetes Research and …, 2021 - Elsevier
Abstract Aims Sphingolipids (SPs) and their substrates and constituents, fatty acids (FAs),
are implicated in the pathogenesis of various metabolic diseases associated. This study …

Serum Sphingolipids Aiding the Diagnosis of Adult HIV-Negative Patients with Talaromyces marneffei Infection

ZT Li, LF Yau, Y Qiu, SQ Li, YQ Zhan… - Frontiers in Cellular …, 2021 - frontiersin.org
Increasing attention has been directed to Talaromyces marneffei (T. marneffei) infection in
HIV-negative patients due to its high mortality rate. However, nonspecific symptoms and …

Editorial for BBRC lipidomics special issue

S Spiegel, J Ntambi - Biochemical and biophysical research …, 2018 - ncbi.nlm.nih.gov
The ability to analyze large numbers of lipids and metabolites has greatly advanced the
understanding of their biochemical functions and roles in disease, but has also created …

Target lipidomics reveals associations between serum sphingolipids and insulin sensitivity by the glucose clamp

J Ye, X Ye, W Jiang, C Lu, X Geng, C Zhao, Y Ma… - bioRxiv, 2020 - biorxiv.org
Background This study aimed to systematically investigate the associations between serum
sphingolipids and insulin sensitivity as well as insulin secretion. This study also aimed to …

Sphingolipid metabolism in human melanoma and the influence of antitumor peptides

T Fingerlos - unipub.uni-graz.at
Zusammenfassung Ein Derivat des humanen Lactoferricin, RDP22, ist ein potentieller
Kandidat für eine neue Krebstherapie, da es in der Lage ist Krebszellen zu töten durch …