Increasing evidence corroborates the fundamental role of neuroinflammation in the
development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the …

Neurodevelopmental disorders are characterized by relatively early onset, with temporal
variations across conditions. These lifelong conditions lead to social and communication …

Medical comorbidities are more common in children with autism spectrum disorders (ASD)
than in the general population. Some genetic disorders are more common in children with …

Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

Defining the multiple roles of the mechanistic (formerly'mammalian') target of rapamycin
(mTOR) signalling pathway in neurological diseases has been an exciting and rapidly …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive
impairment is a frequent comorbidity, but the mechanisms are not fully elucidated. We …

ObjectiveEpilepsy is a chronic neurological disease characterised with seizures. The
aetiology of the most generalised epilepsies cannot be explicitly determined and the …

Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …

Over the past decade enhanced activation of the mammalian target of rapamycin (mTOR)-
signaling cascade has been identified in focal malformations of cortical development (MCD) …