This study aimed to examine the effects of luteolin (LUT) on chronic neuropathic pain (NP)-
induced mood disorders (ie, anxiety and depression) by regulating oxidative stress …

In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of
melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model …

Neuropathic pain (NP) is characterized by its complex and multifactorial nature and limited
responses to opioid therapy; NP is associated with risks of drug resistance, addiction …

Human epidemiological studies suggest that chronic pain can increase mortality risk. We
investigated whether this was true in mice so that underlying mechanisms might be …

Chronic pain, which affects around 1/3 of the world population and is often comorbid with
memory deficit and mood depression, is a leading source of suffering and disability. Studies …

Chronic neuropathy is a common and debilitating problem that poses a significant challenge
to health care worldwide. Natural compounds have received considerable attention as …

When neuropathic pain is maintained long term, it can also lead to the development of
emotional disorders that are even more intense than pain perception and difficult to treat …

Introduction Brachial plexus avulsion (BPA) injury develops frequent and intense
neuropathic pain, involving in both peripheral and central nervous systems. The incidence of …

Repetitive transcranial magnetic stimulation (rTMS) could effectively relieve the pain and
depression in neuropathic pain (NP) patients. However, the specific treatment parameters …

Patients with chronic neuropathic pain (CNP) often complain about their terrible memory,
especially the speed of information processing. Accumulating evidence suggests a possible …