Chemokines are crucial inflammatory mediators needed during an immune response to
clear pathogens. However, their excessive release is the main cause of hyperinflammation …

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …

Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is
attributed to excess deposition of extracellular matrix components including collagen …

Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …

Tissue fibrosis (scarring) is a leading cause of morbidity and mortality. Current treatments for
fibrotic disorders, such as idiopathic pulmonary fibrosis, hepatic fibrosis and systemic …

We characterized the cellular immune response to severe acute respiratory syndrome
coronavirus (SARS-CoV) infection in 12-to 14-month-old BALB/c mice, a model that mimics …

Langerhans cells (LCs) are bone marrow (BM)–derived epidermal dendritic cells (DCs) that
represent a critical immunologic barrier to the external environment, but little is known about …

The lungs present a challenging immunological dilemma for the host. Anatomically
positioned at the environmental interface, they are constantly exposed to antigens …

Infection with pathogenic influenza virus induces severe pulmonary immune pathology, but
the specific cell types that cause this have not been determined. We characterized …

Many of the major diseases, including cardiovascular disease, are widely recognized as
inflammatory diseases. MCP-1 (monocyte chemotactic protein-1) plays a critical role in the …