It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Ethnopharmacological relevance: Worldwide, more than three billion cases of parasitic
disease are reported yearly and it is likely that this figure is substantially under-estimated …

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …

Metabolomics is an emerging and promising omics approach used to understand biological
mechanisms. By untargeted and targeted metabolomics analyses, metabolites are …

Antimicrobial drug resistance is threatening to take us to the “pre‐antibiotic era”, where
people are dying from preventable and treatable diseases and the risk of hospital …

Background Schistosoma infection is a significant public health issue, affecting over 200
million individuals and threatening 700 million people worldwide. The species prevalent in …

During evolution, both human and plant pathogens have evolved to utilize a diverse range
of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major …

Visceral leishmaniasis (VL) is a fatal parasitic disease if untreated. Treatment options of VL
diminish due to emerging drug resistance. Although the principal host cells for the …

Background The disturbance of host metabolic pathways by Leishmania parasites has
crucial consequences for the activation status of immune cells and the outcome of infection …

In Trypanosoma cruzi, the causal agent of Chagas disease, the first seven steps of glycolysis
are compartmentalized in glycosomes, which are authentic but specialized peroxisomes …