The liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic
homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their …

Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which
regulate splice site recognition and spliceosome assembly during precursor messenger …

RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The
mechanisms regulating liver-specific AS profiles and their contribution to liver function are …

Human pluripotent stem cell-derived hepatocytes (hPSC-Heps) may be suitable for treating
liver diseases, but differentiation protocols often fail to yield adult-like cells. We hypothesised …

Non-alcoholic fatty liver disease (NAFLD) is associated with human environmental exposure
to polychlorinated biphenyls (PCBs). Alternative splicing (AS) is dysregulated in steatotic …

Obesity's complex etiology due to the interplay of environment and genetics makes it a more
challenging research and health problem. Some of the contributing genetic factors that have …

Acute liver failure (ALF) is characterized by the rapidly progressive deterioration of hepatic
function, which, without effective medical intervention, results in high mortality and morbidity …

Several preclinical models have been recently developed for metabolic associated fatty liver
disease (MAFLD) and associated hepatocellular carcinoma (HCC) but comprehensive …

Background & Aims The human liver transcriptome is complex and highly dynamic, eg. one
gene may produce multiple distinct transcripts, each with distinct posttranscriptional …

A rampant and urgent global health issue of the 21st century is the emergence and
progression of fatty liver disease (FLD), including alcoholic fatty liver disease and the more …