Uric acid in metabolic syndrome: does uric acid have a definitive role?

S Copur, A Demiray, M Kanbay - European journal of internal medicine, 2022 - Elsevier
Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic
syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty …

Cat and mouse: HIV transcription in latency, immune evasion and cure/remission strategies

A Delannoy, M Poirier, B Bell - Viruses, 2019 - mdpi.com
There is broad scientific and societal consensus that finding a cure for HIV infection must be
pursued. The major barrier to achieving a cure for HIV/AIDS is the capacity of the HIV virus to …

Differential DNA methylation of networked signaling, transcriptional, innate and adaptive immunity, and osteoclastogenesis genes and pathways in gout

Z Wang, Y Zhao, A Phipps‐Green… - Arthritis & …, 2020 - Wiley Online Library
Objective In gout, autoinflammatory responses to urate crystals promote acute arthritis flares,
but the pathogeneses of tophi, chronic synovitis, and erosion are less well understood …

Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson's disease

E Kozina, M Byrne, RJ Smeyne - npj Parkinson's Disease, 2022 - nature.com
Mutations in a number of genes contribute to development of Parkinson's disease (PD),
including several within the LRRK2 gene. However, little is known about the signals that …

The immunomodulatory effect of minocycline on gene expression of inflammation related cytokines in lipopolysaccharide-treated human peripheral blood …

A Rassouli, B Shihmani, J Mehrzad… - Animal …, 2023 - Taylor & Francis
To evaluate the immunomodulatory effect of minocycline, the present study was carried out
on the gene expression of toll-like receptor type-4 (TLR4) and some pro-inflammatory (IL-1β …

Multi-Cell-Type Openness-Weighted Association Studies for Trait-Associated Genomic Segments Prioritization

S Song, H Sun, JS Liu, L Hou - Genes, 2022 - mdpi.com
Openness-weighted association study (OWAS) is a method that leverages the in silico
prediction of chromatin accessibility to prioritize genome-wide association studies (GWAS) …

Identification of key genes and pathways in regulating immune‑induced diseases of dendritic cells by bioinformatic analysis

Y Zheng, X Zheng, S Li, H Zhang… - Molecular …, 2018 - spandidos-publications.com
Dendritic cells (DCs) serve crucial roles in the activation of the immune response, and
imbalance in the activation or inhibition of DCs has been associated with an increased …

Identification of Sulfavant A as the First Synthetic TREM2 Ligand Discloses a Homeostatic Response of Dendritic Cells After Receptor Engagement

C Gallo, E Manzo, G Barra, L Fioretto, M Ziaco… - 2022 - researchsquare.com
The immune response arises from a fine balance of cellular and molecular mechanisms that
provide for surveillance, tolerance, and elimination of dangers as pathogens. Improving the …

[PDF][PDF] Action of Cholera Toxin B Subunit and Peptide LKEKK on 2 Different Cell Types

EV Navolotskaya - Japanese Journal of Gastroenterology and …, 2020 - jajgastrohepto.org
Action of Cholera Toxin B Subunit and Peptide LKEKK on Different Cell Types Page 1 ISSN
2435-1210|Volume 4 Japanese Journal of Gastroenterology and Hepatology Review Article …