ABSTRACT CTCF is a highly conserved zinc-finger DNA-binding protein that mediates
interactions between distant sequences in the genome. As a consequence, CTCF regulates …

In higher eukaryotes, enhancers determine the activation of developmental gene
transcription in specific cell types and stages of embryogenesis. Enhancers transform the …

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

The genome is partitioned into topologically associated domains and genomic
compartments with shared chromatin valence. This architecture is constrained by the DNA …

Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …

The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …

To infer potential causal relationships between 3D chromatin structure, enhancers, and
gene transcription, we mapped each feature in a genome-wide fashion across eight …

The major β‐haemoglobinopathies, sickle cell disease and β‐thalassaemia, represent the
most common monogenic disorders worldwide and a steadily increasing global disease …

During mitosis, transcription is globally attenuated and chromatin architecture is dramatically
reconfigured. We exploited the M-to G1-phase progression to interrogate the contributions of …

Transcription is regulated by transcription factor (TF) binding at promoters and distal
regulatory elements and histone modifications that control the accessibility of these …