The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Highlights•Triazoles mimic different functional groups, resulting optimal bioisosteres for the
synthesis of new active molecules.•Triazoles present a marked stability under hydrolytic …

The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …

Bcr-AblT315I mutation-induced imatinib resistance remains a major challenge for clinical
management of chronic myelogenous leukemia (CML). Herein, we report GZD824 (10a) as …

In the present study, we report the design and synthesis of novel CAN508 sulfonamide-
based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with …

Four new series 7a-e, 8a-e, 9a-e, and 10a-e of 7-aryl-3-substituted pyrazolo [1, 5-a]
pyrimidines were synthesized and tested for their RTK and STK inhibitory activity …

An efficient method for the synthesis of a new class of α-aminophosphonates of imatinib
derivative has been developed in one-pot Kabachnik-Fields reaction of N-(5-amino-2-methyl …

Various polysubstituted pyrimidines are smoothly formed via a base-promoted
intermolecular oxidation C–N bond formation of allylic C (sp3)–H and vinylic C (sp2)–H of …

Motivated by evidence garnered from literature probing the use of triazoles in drug discovery
and development, we reported the utilization of bioisosteric replacement and molecular …

Abstract Three novel series of 1, 2, 3-triazole and 1, 3, 4-oxadiazole derivatives of imatinib
were prepared and evaluated in vitro for their cytostatic effects against a human chronic …