Evaluation and management of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2020 - nature.com
Heart failure with preserved ejection fraction (HFpEF) has grown to become the dominant
form of heart failure worldwide, in tandem with ageing of the general population and the …

Heart failure with preserved ejection fraction in perspective

MA Pfeffer, AM Shah, BA Borlaug - Circulation research, 2019 - Am Heart Assoc
Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association …

B Pieske, C Tschöpe, RA De Boer… - European heart …, 2019 - academic.oup.com
Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF)
remains a challenge. We recommend a new stepwise diagnostic process, the 'HFA–PEFF …

Cardiac Rehabilitation for Patients With Heart Failure: JACC Expert Panel

B Bozkurt, GC Fonarow, LR Goldberg, M Guglin… - Journal of the American …, 2021 - jacc.org
Cardiac rehabilitation is defined as a multidisciplinary program that includes exercise
training, cardiac risk factor modification, psychosocial assessment, and outcomes …

Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality

FH Verbrugge, K Omote, YNV Reddy… - European heart …, 2022 - academic.oup.com
Background A substantial proportion of patients with heart failure (HF) with preserved
ejection fraction (HFpEF) present with normal natriuretic peptide (NP) levels. The …

Exercise Intolerance in Patients With Heart Failure: JACC State-of-the-Art Review

MG Del Buono, R Arena, BA Borlaug, S Carbone… - Journal of the American …, 2019 - jacc.org
Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance,
because it is associated with a poor quality of life and increased mortality. While impaired …

Phenotype-specific treatment of heart failure with preserved ejection fraction: a multiorgan roadmap

SJ Shah, DW Kitzman, BA Borlaug, L Van Heerebeek… - Circulation, 2016 - Am Heart Assoc
Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF
cases, and its prevalence relative to HF with reduced EF continues to rise. In contrast to HF …

Altered hemodynamics and end-organ damage in heart failure: impact on the lung and kidney

FH Verbrugge, M Guazzi, JM Testani, BA Borlaug - Circulation, 2020 - Am Heart Assoc
Heart failure is characterized by pathologic hemodynamic derangements, including elevated
cardiac filling pressures (“backward” failure), which may or may not coexist with reduced …

Heart failure with preserved ejection fraction: mechanisms and treatment strategies

K Omote, FH Verbrugge… - Annual review of medicine, 2022 - annualreviews.org
Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

Evaluation of the effects of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a …

SD Anker, J Butler, GS Filippatos… - European journal of …, 2019 - Wiley Online Library
Background The principal biological processes that characterize heart failure with a
preserved ejection fraction (HFpEF) are systemic inflammation, epicardial adipose tissue …