Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Polycomb group (PcG) protein complexes dynamically define cellular identity through the
regulation of key developmental genes. Important advances in the PcG field have come from …

In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and
correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We …

Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI
compartments contain specific microbiota, and microbiota dysbiosis is associated with …

How regeneration cues are converted into the epigenetic information that controls gene
expression in adult stem cells is currently unknown. We identified an inflammation-activated …

The polycomb group (PcG) proteins are essential for the normal development of multicellular
organisms. They form multi-protein complexes that work as transcriptional repressors of …

For decades, lower-model organisms such as Drosophila melanogaster have often provided
the first glimpse into the mechanism of action of human cancer-related proteins, thus making …

There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …

The study of Drosophila imaginal discs has contributed to a number of discoveries in
developmental and cellular biology. In addition to the elucidation of the role of tissue …

Although cellular tumor-suppression mechanisms are widely studied, little is known about
mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in …