MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Although SIRT7 is a member of sirtuin family proteins that are described as NAD+-
dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …

In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating
communication between cells and environment. The enzymatic activity of the mammalian …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism
and stress responses. It remains elusive how human somatic stem cell populations might be …

MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene
expression by targeting messenger RNA, inducing translational repression and messenger …