Metabolic dysfunction-associated steatotic liver disease (MASLD) originates from a
homeostatic imbalance in hepatic lipid metabolism. Increased fat deposition in the liver of …

Autophagy is an essential quality control mechanism for maintaining organellar functions in
eukaryotic cells. Defective autophagy in pancreatic beta cells has been shown to be …

Aim/hypothesis Hyperglycaemia is associated with alpha cell dysfunction, leading to
dysregulated glucagon secretion in type 1 and type 2 diabetes; however, the mechanisms …

Abstract “Metabolic aging” refers to the gradual decline in cellular metabolic function across
various tissues due to defective hormonal signaling, impaired nutrient sensing …

Aims/hypothesis Protein kinase CK2 acts as a negative regulator of insulin expression in
pancreatic beta cells. This action is mainly mediated by phosphorylation of the transcription …

Objective Glucagon is a critical hormone regulating glucose metabolism. It stimulates the
liver to release glucose under low blood sugar conditions, thereby maintaining blood …

Abstract The coronavirus disease 2019 (COVID-19) pandemic has become the most serious
global public health issue in the past two years, requiring effective therapeutic strategies …

Impairment or dysregulation of autophagy has been implicated in many human pathologies
ranging from neurodegenerative diseases, infectious diseases, cardiovascular diseases …

Hormone synthesis and secretion is a highly regulated process governed by metabolic cues.
Although peptide hormone action is largely governed by the rate of its synthesis and …

Metabolomics refers to the measurement of small molecules in a biological system with the
goal of identifying biochemical mechanisms and markers of cell functions. In many instances …