The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

While nuclear lamina abnormalities are hallmarks of human diseases, their interplay with
epigenetic regulators and precise epigenetic landscape remain poorly understood. Here, we …

Heterochromatin and euchromatin form different spatial compartments in the interphase
nucleus, with heterochromatin being localized mainly at the nuclear periphery. The …

Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic
transport. However, research efforts over the last decade have demonstrated that NPCs and …

Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key
cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC …

In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome
regulation and cellular homeostasis. New discoveries have revealed that the NPC has …

The most common clinical tachyarrhythmia, atrial fibrillation (AF), is present in 1–2% of the
population. Although common risk factors, including hypertension, diabetes, and obesity …

Duchenne's muscular dystrophy is an X-linked neuromuscular disease that manifests as
muscle atrophy and cardiomyopathy in young boys. However, a considerable percentage of …

Nuclear pore complexes are large multicomponent protein complexes that are embedded in
the nuclear envelope, where they mediate nucleocytoplasmic transport. In addition to …