Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer

R Sugiura, R Satoh, T Takasaki - Cells, 2021 - mdpi.com
The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

Traditional uses, ten-years research progress on phytochemistry and pharmacology, and clinical studies of the genus Scutellaria

J Shen, P Li, S Liu, Q Liu, Y Li, Y Sun, C He… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Scutellaria (Lamiaceae), which includes
approximately 360–469 accepted species, is widespread in Europe, North America, East …

Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes

B Liu, L Li, G Liu, W Ding, W Chang, T Xu, X Ji… - Acta Pharmacologica …, 2021 - nature.com
Baicalein is a natural flavonoid extracted from the root of Scutellaria baicalensis that exhibits
a variety of pharmacological activities. In this study, we investigated the molecular …

Baicalein: A metabolite with promising antineoplastic activity

HS Tuli, V Aggarwal, J Kaur, D Aggarwal, G Parashar… - Life Sciences, 2020 - Elsevier
Cancer, being a multifactorial disease has diverse presentation in different subgroups which
is mainly attributed to heterogenous presentation of tumor cells. This cancer cell …

Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives

AKMH Morshed, S Paul, A Hossain, T Basak… - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

Scutellaria baicalensis and Cancer Treatment: Recent Progress and Perspectives in Biomedical and Clinical Studies

CS Cheng, J Chen, HY Tan, N Wang… - The American Journal …, 2018 - World Scientific
Scutellaria baicalensis (Huangqin in Chinese) is a major traditional Chinese medicine
(TCM) herb, which has a long history of use in the treatment of a variety of symptoms …

[HTML][HTML] Non-apoptotic cell death in ovarian cancer: Treatment, resistance and prognosis

J Chen, Z Wei, K Fu, Y Duan, M Zhang, K Li… - Biomedicine & …, 2022 - Elsevier
Ovarian cancer is mostly diagnosed at an advanced stage due to the absence of effective
screening methods and specific symptoms. Repeated chemotherapy resistance and …

Selenocompounds in cancer therapy: an overview

D Bartolini, L Sancineto, AF de Bem, KD Tew… - Advances in Cancer …, 2017 - Elsevier
In vitro and in vivo experimental models clearly demonstrate the efficacy of Se compounds
as anticancer agents, contingent upon chemical structures and concentrations of test …