Therapeutic strategies for enhancing angiogenesis in wound healing

AP Veith, K Henderson, A Spencer, AD Sligar… - Advanced drug delivery …, 2019 - Elsevier
The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

[HTML][HTML] Diabetes and wound angiogenesis

UA Okonkwo, LA DiPietro - International journal of molecular sciences, 2017 - mdpi.com
Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in
sight. Complications of DM2 involve a myriad of comorbidities including the serious …

[HTML][HTML] Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

M Yu, W Liu, J Li, J Lu, H Lu, W Jia, F Liu - Stem cell research & therapy, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes emerge as promising
candidates for treating delayed wound healing in diabetes due to the promotion of …

[HTML][HTML] Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and …

M Pomatto, C Gai, F Negro, M Cedrino… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stem cells isolated from both bone
marrow (BMSCs) and adipose tissue (ADSCs) show potential therapeutic effects. These …

Endothelial cell metabolism

G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

[HTML][HTML] Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat …

X Li, X Xie, W Lian, R Shi, S Han, H Zhang… - … & molecular medicine, 2018 - nature.com
Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with
diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor …

[Retracted] Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Stimulated by Deferoxamine Accelerate Cutaneous Wound Healing by Promoting …

J Ding, X Wang, B Chen, J Zhang… - BioMed research …, 2019 - Wiley Online Library
The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially
used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis …

[HTML][HTML] Exosomes derived from human endothelial progenitor cells accelerate cutaneous wound healing by promoting angiogenesis through Erk1/2 signaling

J Zhang, C Chen, B Hu, X Niu, X Liu… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Chronic skin wounds represent one of the most common and disabling complications of
diabetes. Endothelial progenitor cells (EPCs) are precursors of endothelial cells and can …

GelMA combined with sustained release of HUVECs derived exosomes for promoting cutaneous wound healing and facilitating skin regeneration

D Zhao, Z Yu, Y Li, Y Wang, Q Li, D Han - Journal of molecular histology, 2020 - Springer
It remains a clinical challenge for cutaneous wound healing and skin regeneration.
Endothelial cells participate in the formation of blood vessels and play an important role in …

[HTML][HTML] Crosstalk between oxidative stress and endoplasmic reticulum (ER) stress in endothelial dysfunction and aberrant angiogenesis associated with diabetes: a …

H Maamoun, T Benameur, G Pintus… - Frontiers in …, 2019 - frontiersin.org
Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and
obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro-and …