Simple Summary KRAS is a gene that is commonly mutated in cancer, especially in
pancreatic, lung and colorectal cancers. Despite its importance, scientists have for many …

Abstract Kirsten Rat Sarcoma (KRAS) is a master oncogene involved in cellular proliferation
and survival and is the most commonly mutated oncogene in all cancers. Activating KRAS …

Urothelial carcinoma of the bladder is unique among epithelial carcinomas in its divergent
pathways of tumorigenesis. Low-grade papillary tumours rarely become muscle-invasive …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the potential mechanisms by which farnesyl transferases inhibit tumor growth …

Embracing the transformation of radiation sciences by the recent surge of developments in
molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo …

Rheb proteins represent a novel and unique family of the Ras superfamily GTP-binding
proteins that is conserved from yeast to human. Biochemical studies establish that they bind …

The benzophenone scaffold represents a ubiquitous structure in medicinal chemistry
because it is found in several naturally occurring molecules which exhibit a variety of …

Zinc bioinorganic chemistry has emphasized the role of the metal ion on the structure and
function of the protein. There is, more recently, an increasing appreciation of the role of zinc …

Ras activation promotes the survival of tumor cells after DNA damage. To reverse this
survival advantage, Ras signaling has been targeted for inhibition. Other contributors to Ras …

The mevalonate pathway has become an important target for anti-cancer therapy.
Manipulation of this pathway results in alteration of malignant cell growth and survival in cell …