Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

Thermally activated ion channels are known to detect the entire thermal range from extreme
heat (TRPV2), painful heat (TRPV1, TRPM3 and ANO1), non-painful warmth (TRPV3 and …

The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …

Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel
required for immune cell activation, insulin secretion, and body heat control. TRPM2 is …

Neuropathic pain and hippocampal injury can arise from the overload of diabetes-induced
calcium ion (Ca 2+) entry and oxidative stress. The transient receptor potential (TRP) …

TRPM2 is critically involved in diverse physiological processes including core temperature
sensing, apoptosis, and immune response. TRPM2's activation by Ca2+ and ADP ribose …

In humans, the TRP superfamily of cation channels includes 27 related molecules that
respond to a remarkable variety of chemical and physical stimuli. While physiological roles …