For decades, exercise has been consid-ered a cornerstone of diabetes management, along
with diet and medication. However, high-quality evidence on the importance of exercise and …

Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is
critical for normal function in many cell types. In accordance with the importance of these 4 g …

The accelerated metabolic demands of the working muscle cannot be met without a robust
response from the liver. If not for the hepatic response, sustained exercise would be …

The liver plays a key role for the maintenance of blood glucose homeostasis under widely
changing physiological conditions. In the overnight fasted state, breakdown of hepatic …

Precise regulation of hepatic and peripheral glucose uptake is essential to preserve glucose
homeostasis. The liver extracts∼ 1/3 of an oral glucose load, skeletal muscle extracts∼ 1/3 …

Several studies have demonstrated that oral glucose tolerance is impaired in the immediate
postexercise period. A double-tracer technique was used to examine glucose kinetics during …

The liver plays a central role in the control of glucose production. It is also involved in the
regulation of insulin secretion and sensitivity through neural pathways. This review will …

Background Aerobic exercise training is known to have beneficial effects on whole-body
glucose metabolism in people with type 2 diabetes (T2D). The responses of the liver to such …

Context Insulin resistance (IR) in skeletal muscle contributes to whole body hyperglycemia
and the secondary complications associated with type 2 diabetes. Inositol hexakisphosphate …

Moderate exercise improves insulin sensitivity and reduces triacylglycerol (triglyceride; TG)
concentrations. We hypothesized that changes in insulin sensitivity are an important …