The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments
The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
Status of peripheral sodium channel blockers for non-addictive pain treatment
M Alsaloum, GP Higerd, PR Effraim… - Nature Reviews …, 2020 - nature.com
The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …
used for pain management are often only partially effective, carry dose-limiting adverse …
Animal toxins—Nature's evolutionary-refined toolkit for basic research and drug discovery
V Herzig, B Cristofori-Armstrong, MR Israel… - Biochemical …, 2020 - Elsevier
Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …
Antibodies and venom peptides: new modalities for ion channels
H Wulff, P Christophersen, P Colussi… - Nature Reviews Drug …, 2019 - nature.com
Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …
Structural basis for NaV1.7 inhibition by pore blockers
J Zhang, Y Shi, Z Huang, Y Li, B Yang, J Gong… - Nature Structural & …, 2022 - nature.com
Voltage-gated sodium channel NaV1. 7 plays essential roles in pain and odor perception.
NaV1. 7 variants cause pain disorders. Accordingly, NaV1. 7 has elicited extensive attention …
NaV1. 7 variants cause pain disorders. Accordingly, NaV1. 7 has elicited extensive attention …
Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
Human genetic studies have implicated the voltage-gated sodium channel NaV1. 7 as a
therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated …
therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated …
NaV1. 7 as a pain target–from gene to pharmacology
Abstract Na V 1.7, a subtype of the voltage-gated sodium channel family that is highly
expressed in peripheral sensory neurons, remains one of the most promising targets for the …
expressed in peripheral sensory neurons, remains one of the most promising targets for the …
Sodium channels in human pain disorders: genetics and pharmacogenomics
SD Dib-Hajj, SG Waxman - Annual Review of Neuroscience, 2019 - annualreviews.org
Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …
Fifteen years of NaV1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?
In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …