A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …

Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Introduction We investigated plasma proteomic markers of astrocytopathy, brain
degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset …

Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has
been recognized for decades, but the contribution of the recently described meningeal …

Neurodegenerative diseases are a group of disorders characterized by progressive loss of
certain populations of neurons, which eventually lead to dysfunction. These diseases …

Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath,
which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine …

Abstract In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive
lymphocytes. However, the IL-17 family has widespread expression throughout evolution …

The interaction between peripheral immune cells and the brain is an important component of
the neuroimmune axis. Unconventional T cells, which include natural killer T (NKT) cells …

Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities,
with a prevalence ranging from 2 to 3% in the general population. Decades of preclinical …

Neuroinflammation has been observed in association with neurodegenerative diseases
including Alzheimer's disease (AD). In particular, a positive correlation has been …