[HTML][HTML] Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications

G Maiolino, V Bisogni, G Rossitto… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Atherosclerosis manifests itself clinically at advanced stages when plaques undergo
hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood …

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

R Do, NO Stitziel, HH Won, AB Jørgensen, S Duga… - Nature, 2015 - nature.com
Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance,. When MI occurs early in life, genetic inheritance is a major …

The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research

M Garelnabi, K Lor, J Jin, F Chai, N Santanam - Clinical biochemistry, 2013 - Elsevier
Apolipoprotein A5 (ApoA5) is a key regulator of plasma triglycerides (TG), even though its
plasma concentration is very low compared to other known apoproteins. Over the years …

Low nonfasting triglycerides and reduced all-cause mortality: a mendelian randomization study

M Thomsen, A Varbo, A Tybjærg-Hansen… - Clinical …, 2014 - academic.oup.com
BACKGROUND Increased nonfasting plasma triglycerides marking increased amounts of
cholesterol in remnant lipoproteins are important risk factors for cardiovascular disease, but …

[HTML][HTML] Identifying plausible adverse drug reactions using knowledge extracted from the literature

N Shang, H Xu, TC Rindflesch, T Cohen - Journal of biomedical informatics, 2014 - Elsevier
Pharmacovigilance involves continually monitoring drug safety after drugs are put to market.
To aid this process; algorithms for the identification of strongly correlated drug/adverse drug …

Molecular analysis of a genetic variants panel related to nutrients and metabolism: association with susceptibility to gestational diabetes and cardiometabolic risk in …

M Franzago, F Fraticelli, A Nicolucci… - Journal of diabetes …, 2017 - Wiley Online Library
Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in pregnancy.
Women with a GDM history are at increased risk of developing diabetes and cardiovascular …

Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease

W Dai, Z Zhang, C Yao, S Zhao - Lipids in Health and Disease, 2019 - Springer
Abstract Apolipoprotein C3 (apoC3) and apolipoprotein A5 (apoA5), encoded by
APOA1/C3/A4/A5 gene cluster, are two critical regulators of plasma triglyceride (TG) …

Nutrigenetic variants and cardio-metabolic risk in women with or without gestational diabetes

M Franzago, F Fraticelli, D Marchetti… - Diabetes Research and …, 2018 - Elsevier
Aim Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in
pregnancy and it can be considered a silent risk associated to T2DM and CVD later in life …

Genetic determinants of LDL, lipoprotein (a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk

BG Nordestgaard… - Current opinion in …, 2011 - journals.lww.com
New and known genetic determinants of plasma levels of LDL cholesterol, lipoprotein (a),
and triglyceride-rich lipoproteins are concordant with both the magnitude and direction of the …

Integrative genetic approach facilitates precision strategies for acute myocardial infarction

M Khawaja, R Siddiqui, SS Virani, CI Amos… - Genes, 2023 - mdpi.com
Acute myocardial infarction remains a significant cause of mortality worldwide and its burden
continues to grow. Its pathophysiology is known to be complex and multifactorial, with …