A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge
Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …
challenged by a multitude of pathological conditions. While innovative approaches have …
Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment
Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …
robustness and resilience, enabling adaptation and increasing survival under dynamic …
Biopolymer-based functional composites for medical applications
Over the last decade, numerous biopolymers have received more attention in medical
applications involving novel biomaterials because of their biocompatibility, biodegradability …
applications involving novel biomaterials because of their biocompatibility, biodegradability …
Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?
Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …
bone defects, are a complicated process. There is growing interest in the application of …
The evolution of polystyrene as a cell culture material
Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern
era, propelling dozens of research fields along the way. This review discusses the …
era, propelling dozens of research fields along the way. This review discusses the …
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …
Mechanism of regulation of stem cell differentiation by matrix stiffness
H Lv, L Li, M Sun, Y Zhang, L Chen, Y Rong… - Stem cell research & …, 2015 - Springer
Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …
[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction
AJ Richard, U White, CM Elks, JM Stephens - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …
expanding. Just in the past decade, substantial advances have led to new insights into the …
Collagen promotes higher adhesion, survival and proliferation of mesenchymal stem cells
Mesenchymal stem cells (MSC) can differentiate into several cell types and are desirable
candidates for cell therapy and tissue engineering. However, due to poor cell survival …
candidates for cell therapy and tissue engineering. However, due to poor cell survival …
Articular fibrocartilage-targeted therapy by microtubule stabilization
J Li, H Jiang, Z Lv, Z Sun, C Cheng, G Tan, M Wang… - Science …, 2022 - science.org
The fibrocartilage presented on the joint surface was caused by cartilage injury or
degeneration. There is still a lack of effective strategies for fibrocartilage. Here, we …
degeneration. There is still a lack of effective strategies for fibrocartilage. Here, we …