[HTML][HTML] Programmed and environmental determinants driving neonatal mucosal immune development

N Torow, TW Hand, MW Hornef - Immunity, 2023 - cell.com
The mucosal immune system of neonates goes through successive, non-redundant phases
that support the developmental needs of the infant and ultimately establish immune …

The maternal gut microbiome in pregnancy: implications for the developing immune system

O Koren, L Konnikova, P Brodin, IU Mysorekar… - Nature Reviews …, 2024 - nature.com
The gut microbiome has important roles in host metabolism and immunity, and microbial
dysbiosis affects human physiology and health. Maternal immunity and microbial …

The gene regulatory basis of bystander activation in CD8+ T cells

NB Watson, RK Patel, C Kean, J Veazey… - Science …, 2024 - science.org
CD8+ T cells are classically recognized as adaptive lymphocytes based on their ability to
recognize specific foreign antigens and mount memory responses. However, recent studies …

Shaping immunity for life: Layered development of CD8+ T cells

C Tabilas, NL Smith, BD Rudd - Immunological reviews, 2023 - Wiley Online Library
Historically, the immune system was believed to develop along a linear axis of maturity from
fetal life to adulthood. Now, it is clear that distinct layers of immune cells are generated from …

Natural Microbial Exposure from the Earliest Natural Time Point Enhances Immune Development by Expanding Immune Cell Progenitors and Mature Immune Cells

S Burger, T Stenger, M Pierson, A Sridhar… - The Journal of …, 2023 - journals.aai.org
Microbial experience fundamentally shapes immunity, particularly during the perinatal
period when the immune system is underdeveloped, and novel microbial encounters are …

Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease

Q Liu, T Pickett, D Hodge, C Rios, M Arnold… - Nature …, 2024 - nature.com
The National Institute of Allergy and Infectious Diseases (NIAID) hosted a two-day virtual
workshop on leveraging microbial exposure to improve mouse models of human immune …

The impact of prenatal inflammation on hematopoietic development

NA Tseng, AE Beaudin - Current Opinion in Hematology, 2023 - journals.lww.com
The impact of prenatal inflammation on hematopoietic develop... : Current Opinion in
Hematology The impact of prenatal inflammation on hematopoietic development : Current …

Role of innate T cells in necrotizing enterocolitis

J Liu, S Joseph, K Manohar, J Lee, JP Brokaw… - Frontiers in …, 2024 - frontiersin.org
Necrotizing enterocolitis (NEC) is a destructive gastrointestinal disease primarily affecting
preterm babies. Despite advancements in neonatal care, NEC remains a significant cause of …

Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines

C Montenegro, F Perdomo-Celis, MA Franco - Viruses, 2024 - mdpi.com
Rotavirus infection continues to be a significant public health problem in developing
countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines …

Host–gut microbiota interactions during pregnancy

KR Amato, P Pradhan, EK Mallott… - … , Medicine, and Public …, 2024 - academic.oup.com
Mammalian pregnancy is characterized by a well-known suite of physiological changes that
support fetal growth and development, thereby positively affecting both maternal and …