Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host
hepatocytes synthesize primary bile acids from cholesterol. Once these host-derived primary …

Liver diseases represent a critical health problem with 2 million deaths worldwide per year,
mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the …

Background Bile salt hydrolase plays an important role in bile acid-mediated signaling
pathways, which regulate lipid absorption, glucose metabolism, and energy homeostasis …

FXR agonists have demonstrated very promising clinical results in the treatment of liver
disorders such as primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and …

Clostridioides difficile infection (CDI) is associated with increasing morbidity and mortality
posing an urgent threat to public health. Recurrence of CDI after successful treatment with …

The gut and the liver have a bidirectional communication via the biliary system and the
portal vein. The intestinal microbiota and microbial products play an important role for …

The gut microbiome plays a major role in human health, and gut microbial imbalance or
dysbiosis is associated with disease development. Modulation in the gut microbiome can be …

Ursodeoxycholic acid (commercially available as ursodiol) is a naturally occurring bile acid
that is used to treat a variety of hepatic and gastrointestinal diseases. Ursodiol can modulate …

Несмотря на успехи, достигнутые в последнее время в лечении хронических
заболеваний печени, в клинической практике нередки ситуации, когда назначение …

Ursodeoxycholic acid (UDCA) is widely recognized as an effective compound in the
treatment of chronic hepatitis and is known to modulate the redox state of the liver …