The genetically informed neurobiology of addiction (GINA) model
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
Emerging phenotyping strategies will advance our understanding of psychiatric genetics
S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …
identified numerous significant loci. Whereas these studies initially depended on cohorts …
[HTML][HTML] CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …
act prematurely and is associated with multiple forms of psychopathology, including …
[HTML][HTML] Symptoms of depression, anxiety, and post-traumatic stress disorder and their relationship to health-related behaviors in over 12,000 US military personnel: Bi …
A Hruby, HR Lieberman, TJ Smith - Journal of affective disorders, 2021 - Elsevier
Background Military personnel are at greater risk of psychological disorders and related
symptoms than civilians. Limited participation in health-promoting behaviors may increase …
symptoms than civilians. Limited participation in health-promoting behaviors may increase …
Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …
than others. Understanding the shared genetic influences underlying the comorbidity …
[HTML][HTML] Disease-and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of …
Background Migraine is a primary headache with genetic susceptibility, but the
pathophysiological mechanisms are poorly understood, and it remains an unmet medical …
pathophysiological mechanisms are poorly understood, and it remains an unmet medical …
[HTML][HTML] Genome-wide placental gene methylations in gestational diabetes mellitus, fetal growth and metabolic health biomarkers in cord blood
WJ Wang, R Huang, T Zheng, Q Du, MN Yang… - Frontiers in …, 2022 - frontiersin.org
Gestational diabetes mellitus (GDM)“program” an elevated risk of metabolic syndrome in the
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …
[HTML][HTML] The GWAS analysis of body size and population verification of related SNPs in Hu sheep
J Jiang, Y Cao, H Shan, J Wu, X Song, Y Jiang - Frontiers in genetics, 2021 - frontiersin.org
Body size is an important indicator of growth and health in sheep. In the present study, we
performed Genome-Wide Association Studies (GWAS) to detect significant single-nucleotide …
performed Genome-Wide Association Studies (GWAS) to detect significant single-nucleotide …
[HTML][HTML] Genome wide association study in Swedish Labrador retrievers identifies genetic loci associated with hip dysplasia and body weight
IN Kieler, SM Persson, R Hagman, VD Marinescu… - Scientific Reports, 2024 - nature.com
Genome wide association studies (GWAS) have been utilized to identify genetic risk loci
associated with both simple and complex inherited disorders. Here, we performed a GWAS …
associated with both simple and complex inherited disorders. Here, we performed a GWAS …
[HTML][HTML] Smoking status and type 2 diabetes, and cardiovascular disease: a comprehensive analysis of shared genetic etiology and causal relationship
Objective This study aimed to explore shared genetic etiology and the causality between
smoking status and type 2 diabetes (T2D), cardiovascular diseases (CVDs), and related …
smoking status and type 2 diabetes (T2D), cardiovascular diseases (CVDs), and related …