The genetically informed neurobiology of addiction (GINA) model

R Bogdan, AS Hatoum, EC Johnson… - Nature Reviews …, 2023 - nature.com
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Emerging phenotyping strategies will advance our understanding of psychiatric genetics

S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

[HTML][HTML] CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …

[HTML][HTML] Symptoms of depression, anxiety, and post-traumatic stress disorder and their relationship to health-related behaviors in over 12,000 US military personnel: Bi …

A Hruby, HR Lieberman, TJ Smith - Journal of affective disorders, 2021 - Elsevier
Background Military personnel are at greater risk of psychological disorders and related
symptoms than civilians. Limited participation in health-promoting behaviors may increase …

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders

D Koller, E Friligkou, B Stiltner, GA Pathak… - Molecular …, 2024 - nature.com
Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

[HTML][HTML] Disease-and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of …

T Aczél, B Benczik, B Ágg, T Körtési, P Urbán… - The Journal of …, 2022 - Springer
Background Migraine is a primary headache with genetic susceptibility, but the
pathophysiological mechanisms are poorly understood, and it remains an unmet medical …

[HTML][HTML] Genome-wide placental gene methylations in gestational diabetes mellitus, fetal growth and metabolic health biomarkers in cord blood

WJ Wang, R Huang, T Zheng, Q Du, MN Yang… - Frontiers in …, 2022 - frontiersin.org
Gestational diabetes mellitus (GDM)“program” an elevated risk of metabolic syndrome in the
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …

[HTML][HTML] The GWAS analysis of body size and population verification of related SNPs in Hu sheep

J Jiang, Y Cao, H Shan, J Wu, X Song, Y Jiang - Frontiers in genetics, 2021 - frontiersin.org
Body size is an important indicator of growth and health in sheep. In the present study, we
performed Genome-Wide Association Studies (GWAS) to detect significant single-nucleotide …

[HTML][HTML] Genome wide association study in Swedish Labrador retrievers identifies genetic loci associated with hip dysplasia and body weight

IN Kieler, SM Persson, R Hagman, VD Marinescu… - Scientific Reports, 2024 - nature.com
Genome wide association studies (GWAS) have been utilized to identify genetic risk loci
associated with both simple and complex inherited disorders. Here, we performed a GWAS …

[HTML][HTML] Smoking status and type 2 diabetes, and cardiovascular disease: a comprehensive analysis of shared genetic etiology and causal relationship

Y Chi, X Wang, J Jia, T Huang - Frontiers in endocrinology, 2022 - frontiersin.org
Objective This study aimed to explore shared genetic etiology and the causality between
smoking status and type 2 diabetes (T2D), cardiovascular diseases (CVDs), and related …