Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives
Diabetes mellitus (DM) is a chronic metabolic disease which causes millions of death all
over the world each year, and its incidence is on increase. The most prevalent form, type 2 …
over the world each year, and its incidence is on increase. The most prevalent form, type 2 …
[HTML][HTML] Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy
P Koutsifeli, U Varma, LJ Daniels, M Annandale… - Journal of Biological …, 2022 - ASBMB
Autophagy is an essential cellular process involving degradation of superfluous or defective
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …
[HTML][HTML] Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia
AS Alqahtani, S Hidayathulla, MT Rehman… - Biomolecules, 2019 - mdpi.com
Nuxia oppositifolia is traditionally used in diabetes treatment in many Arabian countries;
however, scientific evidence is lacking. Hence, the present study explored the antidiabetic …
however, scientific evidence is lacking. Hence, the present study explored the antidiabetic …
[HTML][HTML] Antioxidant, antidiabetic, anticholinergic, and antiglaucoma effects of magnofluorine
Magnofluorine, a secondary metabolite commonly found in various plants, has
pharmacological potential; however, its antioxidant and enzyme inhibition effects have not …
pharmacological potential; however, its antioxidant and enzyme inhibition effects have not …
[HTML][HTML] Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity
New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1)
are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse …
are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse …
Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking …
Sulfonamide derivatives exhibit a wide biological activity and can function as potential
medical molecules in the development of a drug. Studies have reported that the compounds …
medical molecules in the development of a drug. Studies have reported that the compounds …
Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors
The underlying cause of many metabolic diseases is abnormal changes in enzyme activity
in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; …
in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; …
Synthesis, characterization, and inhibition study of novel substituted phenylureido sulfaguanidine derivatives as α‐glycosidase and cholinesterase inhibitors
A series of six N‐carbamimidoyl‐4‐(3‐substituted phenylureido) benzenesulfonamide
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …
Simulated gastrointestinal digestion of camel and bovine casein hydrolysates: Identification and characterization of novel anti-diabetic bioactive peptides
Camel milk proteins are an important substrate for bioactive peptides generation. This study
investigates in-vitro antidiabetic effect (via inhibition of α-amylase (AA), α-glucosidase (AG) …
investigates in-vitro antidiabetic effect (via inhibition of α-amylase (AA), α-glucosidase (AG) …
Multifunctional bioactive peptides derived from quinoa protein hydrolysates: Inhibition of α-glucosidase, dipeptidyl peptidase-IV and angiotensin I converting enzymes
The study aimed to characterize and identify anti-diabetic and anti-hypertensive bioactive
peptides generated upon enzymatic hydrolysis of quinoa protein isolates. Different quinoa …
peptides generated upon enzymatic hydrolysis of quinoa protein isolates. Different quinoa …