Trans-omics: how to reconstruct biochemical networks across multiple 'omic'layers
We propose 'trans-omic'analysis for reconstructing global biochemical networks across
multiple omic layers by use of both multi-omic measurements and computational data …
multiple omic layers by use of both multi-omic measurements and computational data …
New perspectives, opportunities, and challenges in exploring the human protein kinome
LJ Wilson, A Linley, DE Hammond, FE Hood… - Cancer research, 2018 - AACR
The human protein kinome comprises 535 proteins that, with the exception of approximately
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
50 pseudokinases, control intracellular signaling networks by catalyzing the phosphorylation …
WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs
WebGestalt is a popular tool for the interpretation of gene lists derived from large scale-
omics studies. In the 2019 update, WebGestalt supports 12 organisms, 342 gene identifiers …
omics studies. In the 2019 update, WebGestalt supports 12 organisms, 342 gene identifiers …
dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications
Abstract The dbPTM (http://dbPTM. mbc. nctu. edu. tw/) has been maintained for over 10
years with the aim to provide functional and structural analyses for post-translational …
years with the aim to provide functional and structural analyses for post-translational …
dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications
Protein post-translational modifications (PTMs) play an important role in different cellular
processes. In view of the importance of PTMs in cellular functions and the massive data …
processes. In view of the importance of PTMs in cellular functions and the massive data …
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies
Inhibitors targeting KRASG12C, a mutant form of the guanosine triphosphatase (GTPase)
KRAS, are a promising new class of oncogene-specific therapeutics for the treatment of …
KRAS, are a promising new class of oncogene-specific therapeutics for the treatment of …
[HTML][HTML] Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
Transcriptional reprogramming of cellular metabolism is a hallmark of cancer. However,
systematic approaches to study the role of transcriptional regulators (TRs) in mediating …
systematic approaches to study the role of transcriptional regulators (TRs) in mediating …
dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins
KY Huang, MG Su, HJ Kao, YC Hsieh… - Nucleic acids …, 2016 - academic.oup.com
Owing to the importance of the post-translational modifications (PTMs) of proteins in
regulating biological processes, the dbPTM (http://dbPTM. mbc. nctu. edu. tw/) was …
regulating biological processes, the dbPTM (http://dbPTM. mbc. nctu. edu. tw/) was …
[HTML][HTML] Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1
TL Toft-Bertelsen, D Barbuskaite, EK Heerfordt… - Fluids and barriers of the …, 2022 - Springer
Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …
[HTML][HTML] Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources
Mass spectrometry-based phosphoproteomics is becoming an essential methodology for the
study of global cellular signaling. Numerous bioinformatics resources are available to …
study of global cellular signaling. Numerous bioinformatics resources are available to …