Although new agents are implemented to cancer therapy, we lack fundamental
understandings of the mechanisms of chemoresistance, the main obstacle to cure in cancer …

Purpose: Metastatic melanoma is largely unresponsive to DNA-damaging chemotherapy
agents, although WTp53 is frequently detected. Several isoforms of p53 have been …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer
agent that kills various tumor cells without damaging normal tissues. However, many …

Chlamydia trachomatis and human papilloma virus (HPV) are the two most common
sexually transmitted infections among women. HPV infection can increase the risk of cervical …

We describe a new program called cryptic splice finder (CSF) that can reliably identify cryptic
splice sites (css), so providing a useful tool to help investigate splicing mutations in genetic …

Background Several isoforrns of p53 have been reported, which may have varying functions
and expressions. This study aimed to analyze the expression patterns of p53 isoforms in …

The transcription factor nuclear factor-κB (NF-κB) is crucial for the maintenance of
homeostasis. It is incompletely understood how nuclear NF-κB and the crosstalk of NF-κB …

Upon DNA damage and other stresses, the transcription factor p53 elicits numerous
responses including DNA repair, cell cycle arrest and apoptosis, properties that make p53 …

Background: Pakistan has a high incidence of breast cancer in Asia, where annually 16,232
deaths are reported. There are many exogenous and endogenous risk factors that affect the …

We had previously reported that RBEL1A, a novel Ras-like GTPase, was overexpressed in
multiple human malignancies and that its depletion suppressed cell growth. However, the …