[HTML][HTML] Biologics, theranostics, and personalized medicine in drug delivery systems

M Puccetti, M Pariano, A Schoubben… - Pharmacological …, 2024 - Elsevier
The progress in human disease treatment can be greatly advanced through the
implementation of nanomedicine. This approach involves targeted and cell-specific therapy …

Emerging applications and prospects of NFκB decoy oligodeoxynucleotides in managing respiratory diseases

JK Datsyuk, KR Paudel, R Rajput, S Kokkinis… - Chemico-biological …, 2023 - Elsevier
Chronic respiratory diseases like asthma and Chronic Obstructive Pulmonary Disease
(COPD) have been a burden to society for an extended period. Currently, there are only …

Severe asthma remissions induced by biologics targeting IL5/IL5r: results from a multicenter real-life study

A Maglio, C Vitale, C Pelaia, M D'Amato… - International Journal of …, 2023 - mdpi.com
Add-on biological therapy has proven to be effective in many patients with severe
eosinophilic asthma. In this observational multicenter retrospective study, we report the …

Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?

M Cazzola, CP Page, MG Matera… - European …, 2023 - Eur Respiratory Soc
Several current guidelines/strategies outline a treatment approach to asthma, which
primarily consider the goals of improving lung function and quality of life and reducing …

Inhaled RNA drugs to treat lung diseases: Disease-related cells and nano–bio interactions

M Zhang, H Lu, L Xie, X Liu, D Cun, M Yang - Advanced Drug Delivery …, 2023 - Elsevier
In recent years, RNA-based therapies have gained much attention as biomedicines due to
their remarkable therapeutic effects with high specificity and potency. Lung diseases offer a …

Emerging role for interferons in respiratory viral infections and childhood asthma

A Bosco - Frontiers in Immunology, 2023 - frontiersin.org
Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe
lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the …

Baseline characteristics of patients enrolled in clinical trials of biologics for severe asthma as potential predictors of outcomes

F Menzella - Journal of Clinical Medicine, 2023 - mdpi.com
(1) Background: Over the past 20 years, monoclonal antibodies have been developed for
the treatment of severe asthma, with numerous randomised controlled trials (RCTs) …

The role of eosinophil-derived neurotoxin and vascular endothelial growth factor in the pathogenesis of eosinophilic asthma

M Tota, J Łacwik, J Laska, Ł Sędek, K Gomułka - Cells, 2023 - mdpi.com
Asthma is a chronic complex pulmonary disease characterized by airway inflammation,
remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and …

CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy

MM Taheri, F Javan, M Poudineh, SS Athari - Clinical Reviews in Allergy & …, 2024 - Springer
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant
potential for managing inflammatory disorders like asthma. Activating iNKT induces …

[HTML][HTML] Cellular probing using phytoceuticals encapsulated advanced delivery systems in ameliorating lung diseases: Current trends and future prospects

JK Datsyuk, G De Rubis, KR Paudel, S Kokkinis… - International …, 2024 - Elsevier
Chronic respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD) and
asthma have posed a significant healthcare and economic cost over a prolonged duration …