In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting
Gram-negative bacteria, predominantly affecting immunocompromised patients, but its …

Pseudomonas aeruginosa global clones associated with multidrug-resistant (MDR) and
extensively drug-resistant (XDR) phenotypes, denominated high-risk clones, are a growing …

Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Antibiotic resistance is the most challenging clinical and public health problem. Despite of
living in the era of novel technologies in biomedical research, many of untreatable infectious …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

The increasing prevalence of chronic and hospital-acquired infections produced by
multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa …

Antibiotic resistance has increased markedly in gram-negative bacteria over the last two
decades, and in many cases has been associated with increased mortality and healthcare …

Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …

Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …