The mechanism of genome replication and transcription in bunyaviruses

H Malet, HM Williams, S Cusack, M Rosenthal - PLoS pathogens, 2023 - journals.plos.org
Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …

Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family

B Arragain, M Pelosse, A Thompson… - Nature …, 2023 - nature.com
Abstract Tilapia Lake Virus (TiLV), a recently discovered pathogen of tilapia fish, belongs to
the Amnoonviridae family from the Articulavirales order. Its ten genome segments have …

Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers

Q Durieux Trouilleton, D Housset, P Tarillon… - Nature …, 2024 - nature.com
Hantaan virus is a dangerous human pathogen whose segmented negative-stranded RNA
genome is replicated and transcribed by a virally-encoded multi-functional polymerase …

Structural snapshots of phenuivirus cap-snatching and transcription

HM Williams, SR Thorkelsson, D Vogel… - Nucleic Acids …, 2024 - academic.oup.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a human pathogen that is
now endemic to several East Asian countries. The viral large (L) protein catalyzes viral …

Structural and functional characterization of the Sin Nombre virus L protein

K Meier, SR Thorkelsson, Q Durieux Trouilleton… - PLoS …, 2023 - journals.plos.org
The Bunyavirales order is a large and diverse group of segmented negative-strand RNA
viruses. Several virus families within this order contain important human pathogens …

A natural variation in the RNA polymerase of severe fever with thrombocytopenia syndrome virus enhances viral replication and in vivo virulence

K Jeon, HJ Ro, JG Kang, DE Jeong… - Journal of Medical …, 2023 - Wiley Online Library
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick‐borne disease
with high mortality in Eastern Asia. The disease is caused by the SFTS virus (SFTSV), also …

Limited high-throughput screening compatibility of the phenuivirus cap-binding domain

J Scherf, D Vogel, S Gul, J Reinshagen, P Gribbon… - Scientific Reports, 2023 - nature.com
Bunyaviruses constitute a large and diverse group of viruses encompassing many emerging
pathogens, such as Rift Valley fever virus (family Phenuiviridae), with public and veterinary …

Structural characterization of the full-length Hantaan virus polymerase

JR Keown, L Carrique, BE Nilsson-Payant… - PLoS …, 2024 - journals.plos.org
Hantaviridae are a family of segmented negative-sense RNA viruses that contains important
human and animal pathogens. Hantaviridae contain a viral RNA-dependent RNA …

The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses

X Zhang, L Yan, B Liu, C Zhou, X Yu - Microbiology Spectrum, 2024 - journals.asm.org
The heterogeneous nuclear ribonucleoprotein (hnRNP A2B1) is a key component of the
hnRNP complex involving RNA modulation in eukaryotic cells and it has also been reported …

[HTML][HTML] Discovery of novel favipiravir derivatives with improved pharmacokinetic properties as anti-SFTSV agents

X He, F Wu, W Li, R Zhang, R Sun, Z Hu… - European Journal of …, 2024 - Elsevier
Favipiravir is a nucleobase analogue that exhibits antiviral activities against a variety of RNA
viruses. Due to the lack of antivirals to combat SFTS, an emerging tickborne epidemic …