An update on Toscana virus distribution, genetics, medical and diagnostic aspects

N Ayhan, RN Charrel - Clinical Microbiology and Infection, 2020 - Elsevier
Background Toscana virus is an arbovirus transmitted by sand flies within the Mediterranean
area where it can cause febrile illness and neuroinvasive infections during the seasonal …

[HTML][HTML] Sex and age as determinants of the seroprevalence of anti-measles IgG among European healthcare workers: A systematic review and meta-analysis

FP Bianchi, P Stefanizzi, P Trerotoli, S Tafuri - Vaccine, 2022 - Elsevier
Introduction The international literature shows good evidence of a significant rate of measles
susceptibility among healthcare workers (HCWs). As such, they are an important public …

[HTML][HTML] Improved diagnosis of viral encephalitis in adult and pediatric hematological patients using viral metagenomics

EC Carbo, EP Buddingh, E Karelioti, IA Sidorov… - Journal of Clinical …, 2020 - Elsevier
Metagenomic sequencing is a powerful technique that enables detection of the full spectrum
of pathogens present in any specimen in a single test. Hence, metagenomics is increasingly …

Two years of viral metagenomics in a tertiary diagnostics unit: evaluation of the first 105 cases

V Kufner, A Plate, S Schmutz, DL Braun, HF Günthard… - Genes, 2019 - mdpi.com
Metagenomic next-generation sequencing (mNGS) can capture the full spectrum of viral
pathogens in a specimen and has the potential to become an all-in-one solution for virus …

[HTML][HTML] Rapid and sensitive single-sample viral metagenomics using Nanopore Flongle sequencing

I Pichler, S Schmutz, G Ziltener, M Zaheri… - Journal of Virological …, 2023 - Elsevier
The ability of viral metagenomic Next-Generation Sequencing (mNGS) to unbiasedly detect
nucleic acids in a clinical sample is a powerful tool for advanced diagnosis of viral infections …

Canine meningoencephalitis of unknown origin—the search for infectious agents in the cerebrospinal fluid via deep sequencing

JN Nessler, WK Jo, ADME Osterhaus… - Frontiers in Veterinary …, 2021 - frontiersin.org
Meningoencephalitis of unknown origin (MUO) describes a group of meningoencephalitides
in dogs with a hitherto unknown trigger. An infectious agent has been suggested as one …

[HTML][HTML] Infectious Toscana virus in seminal fluid of young man returning from Elba island, Italy

G Matusali, A D'Abramo, C Terrosi… - Emerging Infectious …, 2022 - ncbi.nlm.nih.gov
We report detecting infectious Toscana virus in the seminal fluid of a 25-year-old man from
Italy returning from Elba Island. The presence of infectious virus in human semen adds …

[HTML][HTML] Incubation period for neuroinvasive Toscana virus infections

L Laroche, F Jourdain, N Ayhan, AL Bañuls… - Emerging Infectious …, 2021 - ncbi.nlm.nih.gov
Toscana virus (TOSV) is an emerging pathogen in the Mediterranean area and is
neuroinvasive in its most severe form. Basic knowledge on TOSV biology is limited. We …

Literature review of pathogen agnostic molecular testing of clinical specimens from difficult-to-diagnose patients: implications for public health

DL Downie, P Rao, C David-Ferdon, S Courtney… - Health …, 2024 - liebertpub.com
To better identify emerging or reemerging pathogens in patients with difficult-to-diagnose
infections, it is important to improve access to advanced molecular testing methods. This is …

Direct metagenomic diagnosis of community-acquired meningitis: state of the art

M Morsli, JP Lavigne, M Drancourt - Frontiers in Microbiology, 2022 - frontiersin.org
Current routine diagnosis of community-acquired meningitis (CAM) by multiplex real-time
polymerase chain reaction (RT-PCR) is limited in the number of tested pathogens and their …