[HTML][HTML] Immunology of COVID-19: current state of the science

N Vabret, GJ Britton, C Gruber, S Hegde, J Kim… - Immunity, 2020 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin

CJ Mycroft-West, D Su, I Pagani… - Thrombosis and …, 2020 - thieme-connect.com
The dependence of development and homeostasis in animals on the interaction of hundreds
of extracellular regulatory proteins with the peri-and extracellular glycosaminoglycan …

Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

M Stravalaci, I Pagani, EM Paraboschi, M Pedotti… - Nature …, 2022 - nature.com
The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …

Repurposing chloroquine against multiple diseases with special attention to SARS-CoV-2 and associated toxicity

S Kamat, M Kumari - Frontiers in Pharmacology, 2021 - frontiersin.org
Chloroquine and its derivatives have been used since ages to treat malaria and have also
been approved by the FDA to treat autoimmune diseases. The drug employs pH-dependent …

Fast inactivation of SARS-CoV-2 by UV-C and ozone exposure on different materials

E Criscuolo, RA Diotti, R Ferrarese… - Emerging Microbes & …, 2021 - Taylor & Francis
The extremely rapid spread of the SARS-CoV-2 has already resulted in more than 1 million
reported deaths of coronavirus disease 2019 (COVID-19). The ability of infectious particles …

Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues

L Persoons, E Vanderlinden, L Vangeel, X Wang… - Antiviral research, 2021 - Elsevier
In this study, a series of 10 quinoline analogues was evaluated for their in vitro antiviral
activity against a panel of alpha-and beta-coronaviruses, including the severe acute …

The need for speed and efficiency: a brief review of small molecule antivirals for COVID-19

AC Puhl, TR Lane, F Urbina, S Ekins - Frontiers in Drug Discovery, 2022 - frontiersin.org
While we currently have multiple highly effective vaccines approved for use against SARS-
CoV-2 in the USA and other countries, there are far fewer small molecule antivirals …

Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside

YO Ayipo, SN Yahaya, WA Alananzeh… - Infection, Genetics and …, 2021 - Elsevier
Since the emergence of their primitive strains, the complexity surrounding their
pathogenesis, constant genetic mutation and translation are contributing factors to the …

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

P Procacci, M Macchiagodena, M Pagliai… - Chemical …, 2020 - pubs.rsc.org
Using a combination of enhanced sampling molecular dynamics techniques and non-
equilibrium alchemical transformations with full atomistic details, we have shown that …

Identifying and repurposing antiviral drugs against severe acute respiratory syndrome coronavirus 2 with in silico and in vitro approaches

K Watashi - Biochemical and Biophysical Research …, 2021 - Elsevier
Abstract Coronavirus infectious diseases 2019 (COVID-19), a global pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a serious public …