Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

GPRC6A (GPCR, class C, group 6, subtype A) is a class C GPCR that has been cloned from
human, mouse and rat. Several groups have shown that the receptor is activated by a range …

Activation of the NLRP3 inflammasome enables monocytes and macrophages to release
high levels of interleukin-1β during inflammatory responses. Concentrations of extracellular …

Aims/hypothesis Ingested protein is a well-recognised stimulus for glucagon-like peptide-1
(GLP-1) release from intestinal L cells. This study aimed to characterise the molecular …

Although amino acids are dietary nutrients that evoke the secretion of glucagon-like peptide
1 (GLP-1) from intestinal L cells, the precise molecular mechanism (s) by which amino acids …

The possibility that G protein-coupled receptor family C member A (GPRC6A) is the
osteocalcin (Ocn)-sensing G protein-coupled receptor that directly regulates pancreatic β …

The aim of this study was to explore individual amino acid-stimulated GLP-1 responses and
the underlying stimulatory mechanisms, as well as to identify the amino acid-sensing …

Gastrointestinal (GI) polypeptides are secreted from enteroendocrine cells (EEC s). Recent
technical advances and the identification of endogenous and synthetic ligands have …

Emerging evidence supports the hypothesis that the skeleton is an endocrine organ that
regulates energy metabolism through the release of the osteoblast-derived hormone …

The calcium sensing receptor (CaSR) is expressed by subpopulations of neuronal and glial
cells throughout the brain and is activated by extracellular calcium (Ca 2+ o). During …