Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

[HTML][HTML] Exploitation of glycosylation in enveloped virus pathobiology

Y Watanabe, TA Bowden, IA Wilson… - Biochimica et Biophysica …, 2019 - Elsevier
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

[HTML][HTML] SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

F Amanat, M Thapa, T Lei, SMS Ahmed, DC Adelsberg… - Cell, 2021 - cell.com
In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-
derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal …

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

J Hansen, A Baum, KE Pascal, V Russo, S Giordano… - Science, 2020 - science.org
Neutralizing antibodies have become an important tool in treating infectious diseases.
Recently, two separate approaches yielded successful antibody treatments for Ebola—one …

Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease

EA Van Erp, W Luytjes, G Ferwerda… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

KJ Selva, CE Van De Sandt, MM Lemke, CY Lee… - Nature …, 2021 - nature.com
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …

Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

SK Samrat, AM Tharappel, Z Li, H Li - Virus research, 2020 - Elsevier
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern
to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are …

A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus

BM Gunn, WH Yu, MM Karim, JM Brannan… - Cell host & …, 2018 - cell.com
The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …

Antibody responses to viral infections: a structural perspective across three different enveloped viruses

CD Murin, IA Wilson, AB Ward - Nature microbiology, 2019 - nature.com
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …

Structure of the Inmazeb cocktail and resistance to Ebola virus escape

V Rayaprolu, BO Fulton, A Rafique, E Arturo… - Cell host & …, 2023 - cell.com
Monoclonal antibodies can provide important pre-or post-exposure protection against
infectious disease for those not yet vaccinated or in individuals that fail to mount a protective …