Defining the risk of SARS-CoV-2 variants on immune protection
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …
[HTML][HTML] Exploitation of glycosylation in enveloped virus pathobiology
Y Watanabe, TA Bowden, IA Wilson… - Biochimica et Biophysica …, 2019 - Elsevier
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …
[HTML][HTML] SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2
F Amanat, M Thapa, T Lei, SMS Ahmed, DC Adelsberg… - Cell, 2021 - cell.com
In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-
derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal …
derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal …
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
Neutralizing antibodies have become an important tool in treating infectious diseases.
Recently, two separate approaches yielded successful antibody treatments for Ebola—one …
Recently, two separate approaches yielded successful antibody treatments for Ebola—one …
Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease
EA Van Erp, W Luytjes, G Ferwerda… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …
and hospitalization in infants under 1 year of age and there is currently no market-approved …
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …
Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern
to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are …
to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are …
A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus
The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …
therapeutics to limit and prevent outbreaks. Host antibodies against EBOV are critical for …
Antibody responses to viral infections: a structural perspective across three different enveloped viruses
CD Murin, IA Wilson, AB Ward - Nature microbiology, 2019 - nature.com
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …
through the dual role of antibodies in communicating the presence of invading pathogens in …
Structure of the Inmazeb cocktail and resistance to Ebola virus escape
Monoclonal antibodies can provide important pre-or post-exposure protection against
infectious disease for those not yet vaccinated or in individuals that fail to mount a protective …
infectious disease for those not yet vaccinated or in individuals that fail to mount a protective …