The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

The integration of DNA methylation and transcriptional state within single cells is of broad
interest. Several single-cell dual-and multi-omics approaches have been reported that …

In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by
the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies …

DNA methyltransferase 3a (DNMT3a) is an important part of the epigenetic machinery that
stabilizes patterns of activated T cell responses. We hypothesized that donor T cell DNMT3a …

Epigenetic information defines tissue identity and is largely inherited in development
through DNA methylation. While studied mostly for mean differences, methylation also …

High-throughput third-generation nanopore sequencing devices have enormous potential
for simultaneously observing epigenetic modifications in human cells over large regions of …

The efficiency of cell reprogramming in two-dimensional (2D) cultures is limited. Given that
cellular stemness is intimately related to microenvironmental changes, 3D cell cultures have …

Background Transcriptional correlation networks derived from publicly available gene
expression microarrays have been previously shown to be predictive of known gene …

DNA methylation is essential to mammalian development, and dysregulation can cause
serious pathological conditions. Key enzymes responsible for deposition and removal of …

Gene function prediction has been shown to be a useful methodology for leveraging publicly-
available high-throughput datasets from open scientific repositories to identify previously …