Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

The vascular adventitia acts as a biological processing center for the retrieval, integration,
storage, and release of key regulators of vessel wall function. It is the most complex …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose …

Abstract Development of a vascularized tissue is one of the key challenges for the
successful clinical application of tissue engineered constructs. Despite the significant efforts …

An increasing volume of experimental data indicates that the adventitial fibroblast, in both
the pulmonary and systemic circulations, is a critical regulator of vascular wall function in …

A number of important changes take place in the maternal uterine vasculature during the first
few weeks of pregnancy resulting in increased blood flow to the intervillous space. Vascular …

Reactive oxygen species (ROS) are key signaling molecules that regulate vascular function
and structure in physiological conditions. A misbalance between the production and …

Through mechanobiological control of the extracellular matrix, and hence local stiffness,
smooth muscle cells of the media and fibroblasts of the adventitia play important roles in …

In the present review, microvascular remodelling refers to alterations in the structure of
resistance vessels contributing to elevated systemic vascular resistance in hypertension. We …

Morphological and physiological changes in the vasculature have been described in the
evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction …